October 17, 2019

The new Breakthrough INCHES fat loss incinerator by Breakthrough Labz

The Anabolic Cutter

This is our most exciting product release yet! That ripped look is possible with Breakthrough INCHES!

Breakthrough INCHES was designed by Breakthrough Labz to help men and women achieve their lowest body fat possible without muscle loss. This product is perfect for the athlete preparing for the season, a bodybuilder looking for some serious contest prep, or the everyday male or female looking to look and feel their best.

We designed Breakthrough INCHES based off of our popular Shredded-XT by Platinum Nutra. Shredded-XT has been a staple at our Advanced Nutritional Supplements stores since our first year in existence. Shredded-XT's original formula was a non-stimulant based fat loss catalyst that used the underutilized ingredient 11-Oxo, otherwise know as Adrenosterone. It's a very expensive ingredient to use, but we didn't care. We tripled the dosage and improved the formula more than 5 times by using the enteric capsules. Our goal is having the best product out there and still making it affordable.

Highlights of Breakthrough INCHES:

Non-Stimulant Fat Shredder
Minimal Water Retention
Precisely Dosed Anti-Cortisol
Build Strength & Lean Muscle

PLUS, this is Breakthrough Labz' 1st product Made with Enteric Capsule Technology!!!

Enteric Capsule Technology: Increased Absorption

This delivery system is known as an enteric coating. This is usually only used with advanced pharmaceutical products.

The enteric coating that we use contains a pH sensitive polymer, which means that it remains intact in the acidic environment of the stomach (pH 1.5 - 3.5), protecting the contents of the tablet.

After passing through the stomach the coating then disintegrates in the small intestine (duodenum) which has an alkaline environment (pH 6.5 - 7.6).

The enteric coating is inert and simply passes through your system without any effect at all. The coating we use is manufactured by Colorcon, a world leader in the development and manufacturing of delayed and immediate release coatings for both pharmaceutical and dietary supplement products. This coating has been thoroughly proven for both safety and efficacy.

Apart from the protection that this system provides for those ingredients in our enteric coated products which could be damaged by stomach acid, it also prevents any irritation of the gastric mucosa in the stomach, which is common with many supplements and drugs.

What are the Benefits of Enteric Coated Capsules?

For some formulations, Enteric Coated Capsules are an ideal choice. This is because they:

Overwhelmingly increase absorption rates - The absorption of high quality supplements can increase from as low as 10% (depending on the individual) to 80% or more.

Will not dissolve in the mouth – Enteric Coated Capsules are perfect for drugs that are acid-activated, as they prevent the drug from activating in the mouth or esophagus.

Will not irritate the stomach – Many drugs, such as aspirin, can irritate the stomach. Because they pass through the stomach intact, Enteric Coated Capsules avoid this problem.

Can preserve enzyme activity – Most tablets break down in the highly acidic environment of the stomach. Unfortunately, depending on the product’s formulation, this acidic environment can also negatively impact the desired enzyme activity. Enteric Coated Capsules protect the enzymes so that they can be absorbed, at their highest activity levels, in the small intestine.

Take longer to dissolve – While most capsules dissolve within 15 minutes, Enteric Coated Capsules do not dissolve until approximately one to two hours after ingestion, when they reach the small intestine. These capsules can therefore provide a “timed-release” affect.

Although enteric coating is a common technology employed with expensive pharmaceutical medications, it is rarely seen in the nutritional supplement industry!

That’s because most supplements are manufactured to a price rather than from a ‘best science’ perspective. Pharmaceuticals always work because they must be based on ‘best science’ since FDA regulations require proof that they work.

The manufacturer of Xtend-Life claims over 80% absorption of ingredients when using enteric coated capsules. An extremely high level for a nutritional or dietary supplement.

Some experts believe that (in non enteric coated products) the bioavailability of vitamins (i.e. all the contents) is only 10-15% due to damage from gastric juices and enzymes in the stomach. This is a gray area however as there is little conclusive research available dealing with absorption rates since so many individual factors come into play from person to person.

Ingredient Breakdown: No More Proprietary Blends!

1500 mg - Propionyl-L-Carnitine HCL (L-Carnitine Propionate)
300 mg (3-4 times the dosage of other products) - Androst-4-ene-3,11,17-trione (Andrenosterone / 11-Oxo)
75 mg - 3B-hydroxyandrost-5-ene-17-one (DHEA)
15 mg - 6,7-Dihydroxybergamottin (DHB)

4-Androsten-3,11,17-trione (Adrenosterone / 11-Oxo)

Anabolic Adrenal Fat-Burner

Adrenosterone (11-Oxo) will provide the incredible benefits of increased fat loss and muscle hardening.

Adrenosterone is an adrenal corticoid with impressive endocrine activity. Vida indicates an anabolic potency which is 70% that of Testosterone, but with less than half the androgenicity. Sounds great so far. But what we didn't know at first was how good a fat-burner it would prove to be. During beta testing with volunteers, some were reporting extreme weight loss. There was concern because this is supposed to be an anabolic gainer, and some of our heavier testers were losing weight in the double digits! As it turns out, these were the testers who already had some fat to lose, but their strength was soaring as the fat melted away and they all reported feeling great. Libido enhancement is also sometimes reported.

Adrenosterone is suspected to convert into 11-Keto-Testosterone (11-KT), and 11-KT is likely more active than Adrenosterone itself. 11-KT may also give rise to even stronger metabolites of its own, but those are not characterized well enough to speculate on their contributions.

Adrenosterone's main action is it lowers cortisol levels. Cortisol is the main catabolic (muscle-eating) hormone and it also promotes fat gain. Cortisol and testosterone also work in an inverse relationship, so high cortisol levels lower testosterone. Adrenosterone acts as a competitive inhibitor, preventing cortisone from attaching to the 11b-hydroxysteroid dehydrogenase type I reductase. By competing at the receptor, it keeps cortisone from attaching and converting to cortisol through the enzyme. Andrenosterone is found naturally in the body and is released by the adrenal glands. The body uses it as a way to help regulate cortisol levels.

Adrenosterone is widely considered to be a top-shelf, low side effect, lean mass gainer. It also has cortisol lowering effects related to its enzyme inhibiting properties, making it ideally suited for shredding body fat without going catabolic on cutting cycles. Adrenosterone stacks well with DHEA, so a good ratio of the two are used in Breakthrough INCHES. Shut-down is not common with Adrenosterone, or Adrenosterone/DHEA combos. Nevertheless, a mild PCT is recommended after use for men. Breakthrough BALANCE is a perfect PCT, or bridge between Breakthrough INCHES cycles.

Adrenosterone isn't cheap, even after being commercially available for almost 10 years now. That's because it's still the best cutter on the OTC market, so there'll probably always be a premium on it. This is also why only a few companies, including Breakthrough Labz and Platinum Nutra, are using it. At Breakthrough Labz, we don't care about our cost, as long as it's a safe and effective product.

5-Androsten-3b-ol-17-one (Dehydroepiandrosterone / DHEA)

Versatile Corticometric Steroid Hormone

DHEA is a natural hormone which is biosynthesized predominately in the adrenals. Blood levels are relatively high in adolescence but begin to decline rapidly in young adulthood. It is commonly used to promote bone density, support lean muscle mass and hardness, alleviate depression, encourage libido, improve immune function, and sooth inflammatory conditions without the need for catabolic corticoids. Decades of research are available to support the utility of DHEA in these applications, and all these applications can be particularly pertinent to athletes. For example, supraphysiological doses of DHEA increase serum levels of several anabolic androgens. These androgens include the once popular but now scheduled steroid Androstenedione, and conjugated metabolites of DHT like Androsterone. However, concentrations of undesirable hormones like Cortisol and Aldosterone appear unaffected by DHEA administration.

But what about estrogen? Most bros on the internet say DHEA is estrogenic!

In reality, increases in estrogen (E1 and E2), DHT and Testosterone are statistically non-existent, except in women where Testosterone levels can be significantly elevated over their already low baseline.

How can it be that DHEA possesses all these positive attributes with high oral dosing, but doesn't suppress adrenal or testicular axis?

To understand this, we must turn to the field of Endocrinology known as Intracrinology. Basically, all enzymes needed to convert DHEA into androgens are expressed in a cell-specific fashion in the peripheral target tissues. This allows the androgen-sensitive tissues like muscle to use DHEA locally, and control the intracellular concentrations of these newly formed androgens on-site. This means that oral supplementation with exogenous DHEA enables regulated production of androgens, only in appropriate target tissues, without leakage of significant amounts of metabolites into the general circulation. This local/intracrine action minimizes the inappropriate exposure of other tissues to androgens, virtually eliminating the risk of undesirable systemic effects such as testicular shut-down.

But besides the utility of DHEA as an androgen precursor in target tissue, research has also noted an inverse relationship between cardiovascular mortality and plasma DHEA levels in men. This anti-atherogenic action, and reduction in vascular dysfunction is very intriguing. It is commonly believed that estrogen is "heart-healthy" but that androgens are not, so how can this be? In endothelial cells, DHEA is demonstrated to increase the expression of nitric oxide synthase (NOS) and the subsequent secretion of nitric oxide (NO), which is commonly known to regulate the vascular system in a positive way for athletes. NO products are quite abundant these days, and everyone seems to love the pump that NO boosters provide, but DHEA has it all. It offers the positive cardiovascular pump and skeletal benefits of estrogens, plus the muscle-enhancing properties of androgens, without the elevated blood levels or side effects of either.

DHEA is also generally observed to decrease Sex Hormone-Binding Globulin (SHBG) and increase IGF-1 levels in the blood. These are both highly desirable effects because they discourage feedback suppression and promote additional growth. Another encouraging observation is that hCG treatment increases intratesticular DHEA concentrations. This makes a strong argument for the steroidogenic action of DHEA, rather than any suppressive potential, but this is not yet fully characterized. In addition to these peripheral steroidogenic effects, DHEA may also promote central steroidogenic processes by interaction with the NMDA receptor. This is only speculation because LH studies with consistent results in healthy men are hard to find.

So what's the practical potential of DHEA?

In the gym (real world) DHEA can be expected to promote muscular density and hardness after just a few days of use. This rapid response seems related to its notable insulinomimetic activity, which is crucial to the anabolic effect of androgens. It also works well in practically any stack, and doesn't induce any discernable estrogenic or corticogenic sides. On paper, HPTA suppression may be possible. However, it has never actually been observed by this author in himself or any other athlete and is therefore considered extremely unlikely.

L-Carnitine Propionate (O-Propionyl-L-Carnitine / PLCAR)

NO-Boosting and Energizing Amino Acid Ester

PLCAR is a derivative of the amino acid L-Carnitine. It is the Propionate Ester to be specific, and displays superior oral bioavailability over regular, free form L-Carnitine. Supplementation with L-Carnitine (or its esters) can have multiple advantages for athletes.

It stimulates the production of nitric oxide (NO), thus promoting vasodilation and increasing blood circulation. In addition to its NO boosting effect, it also lowers free radical production. The fact that it's an anti-oxidant is a real bonus for an NO booster.

PLCAR assists fatty acid transport into cell mitochondria, and this facilitates an extra means of energy production. With greater anaerobic capacity and peripheral blood flow, better performance and faster muscle growth can be achieved. This all basically translates into more energy and less fat.

PLCAR also possesses some benefits that could be labeled nootropic, like greater concentration, more motivation, better mental energy, faster information processing and a greater sense of well-being.

6,7-Dihydroxybergamottin (DHB)

6 7-dihydroxybergamottin (DHB) is a furanocoumarin found in grapefruit juice, and is commonly associated with the grapefruit juice effect. Normally grapefruit juice interferes with the metabolism of drugs, but DHB prevents the oxidation of some drugs, increasing oral bioavailability.

In layman’s terms, 6 7-dihydroxybergamottin (DHB) increases absorption and remains in the bloodstream longer, yielding better results from supplements.

Benefits of DHB