The name says it all but the profile confirms it: Breakthrough GENETIX
The first ‘Hardcore Series’ product from Breakthrough Labz, and it’s changing the game in the world of nutritional and sports supplements
Bringing Breakthrough GENETIX to market has easily become Breakthrough Labz’ biggest investment yet. This is a non-methylated DSHEA compliant prohormone, and it is like no other. It combines the market’s hottest natural androgens for the strongest profile in androgenic potency available in one single product. We see no other brands willing to make the investment to match a profile like this; it’s that strong.
It is suggested to take Breakthrough GENETIX for 2 months, and then follow up the cycle with Breakthrough BALANCE, and optionally Breakthrough LIMITS, as well.
Breakthrough INCHES can be stacked with GENETIX, but only for advanced users who will responsibly take a PCT immediately following the cycle – Breakthrough BALANCE and LIMITS is recommended for PCT.
So what’s Breakthrough GENETIX contain that makes it so special?
Per serving (2 caps), 30 servings:
- 250mg Epiandrosterone
- 150mg Androsterone
- 20mg 3-Andro
- 50mg DHEA
- 35mg Androsta
WITH ENTERIC COATED CAPSULES… effectively increasing the doses nearly 1.5-2 times due to far higher absorbability!
Highlights of Breakthrough GENETIX:
- All-in-1, fully-dosed, DSHEA-compliant, androgens profile
- Most powerful and effective formula of its kind on the market
- Designed to add muscle strength & growth, muscular endurance, mood, and libido
- Not hepatoxic, so no liver or kidney damage
- Utilizes enteric coated capsules for increased absorption
- No proprietary blend – it is exactly what it shows to be
Let’s look at the ingredients now:
Accelerated fat loss, increased strength, increased lean mass, increased muscle hardness, and improved libido
Epiandrosterone also commonly known as “Epi-Andro” is an anabolic compound which converts into the natural male hormone “DiHydroTestosterone” or “Stanolone”. Epi-Andro is non-methylated and as a result will put little to no stress on the user’s liver. DHT is 5 times more Androgenic than testosterone. As a dry compound, users will experience lean muscle gains while also increasing lipolysis (fat loss).
Epiandrosterone converts to DHT in the body. DHT is our male sex hormone, so it will cause an increase in strength, and it will help maintain muscle mass. What's more, DHT helps inhibit estrogen conversion in the body, so it will help dry out the user and give the impression of a loss of body fat, since water is shed from within cells. Another secret is its ability to bind to SHBG (sex hormone binding globulin), leading to a greater ratio of free testosterone to total testosterone. In the end of the day, it is this 'free testosterone' that really matters, not the total testosterone. Users get the DHT type results of muscle hardness, some fat loss, water loss, increased lean muscle mass, and an increase in libido.
DHT increases strength which allows the user to lift heavier and harder and can tremendously help maintain muscle while the user is in a caloric deficit.
DHT binds to fat and burns it directly and even inhibits the aromatase enzyme so you get little to no conversion of your testosterone to estrogen. As a result it allows you to burn even more body fat while decreasing your risk of shutdown from elevated estrogen.
DHT suppresses SHBG which results in less circulating estrogen and a serious increase in free testosterone levels. (SHBG[Sex Hormone-Binding Globulin] is a protein that is produced by the liver and binds to testosterone, dihydrotestosterone (DHT), and estradiol (an estrogen) and in this bound state, transports these hormones in the blood as a biologically inactive form).
Estrogen is not an issue when using Epiandrosterone. Consequently, the user does not have to worry about water retention and the domino effect of side effects that accompany it. Furthermore, they also do not have to worry about gynecomastia, as it is not possible to have any estrogen aromatization with epi-andro.
Aggression, weight loss, increased strength, anti-estrogen, and libido
Androsterone and Epiandrosterone are essentially the same molecule, with androsterone being the 3-alpha isomer and epiandrosterone being the 3-beta isomer.
Androsterone not only does not convert to estrogen, but it also actually has anti-estrogen effects, making it good to use during a cutting cycle to aid in fat loss.
Androsterone retains about 12.5-15.0% of Testosterone’s androgenicity, so while it is somewhat similar to Epiandrosterone in structure, it is considerably more virilizing qualitatively. It’s decidedly more potent quantitatively as well, and this makes it an excellent pre-workout or pre-competition addition to enhance alpha attitude and competitive aggression. This sensation is commonly referred to as feeling “on” and Androsterone delivers it.
Androsterone blood levels and ratios are also a prominent marker for sexual preference, with high Androsterone levels corresponding to a stronger desire for women. Men with high Androsterone levels are also perceived more positively by women, who tend to view them as trusted alpha types.
Dehydroepiandrosterone / DHEA (5-Androsten-3b-ol-17-one)
Nitric oxide, and muscular density, hardness, and growth
DHEA is a natural hormone which is biosynthesized predominately in the adrenals. Blood levels are relatively high in adolescence but begin to decline rapidly in young adulthood. It is commonly used to promote bone density, support lean muscle mass and hardness, alleviate depression, encourage libido, improve immune function, and sooth inflammatory conditions without the need for catabolic corticoids. Decades of research are available to support the utility of DHEA in these applications, and all these applications can be particularly pertinent to athletes. For example, supraphysiological doses of DHEA increase serum levels of several anabolic androgens. These androgens include the once popular but now scheduled steroid Androstenedione, and conjugated metabolites of DHT like Androsterone. However, concentrations of undesirable hormones like Cortisol and Aldosterone appear unaffected by DHEA administration.
In reality, increases in estrogen (E1 and E2), DHT and Testosterone are statistically non-existent, except in women where Testosterone levels can be significantly elevated over their already low baseline.
How can it be that DHEA possesses all these positive attributes with high oral dosing, but doesn't suppress adrenal or testicular axis? All enzymes needed to convert DHEA into androgens are expressed in a cell-specific fashion in the peripheral target tissues. This allows the androgen-sensitive tissues like muscle to use DHEA locally and control the intracellular concentrations of these newly formed androgens on-site. This means that oral supplementation with exogenous DHEA enables regulated production of androgens, only in appropriate target tissues, without leakage of significant amounts of metabolites into the general circulation. This local/intracrine action minimizes the inappropriate exposure of other tissues to androgens, virtually eliminating the risk of undesirable systemic effects such as testicular shut-down.
But besides the utility of DHEA as an androgen precursor in target tissue, research has also noted an inverse relationship between cardiovascular mortality and plasma DHEA levels in men. This anti-atherogenic action, and reduction in vascular dysfunction is very intriguing. It is commonly believed that estrogen is "heart-healthy" but that androgens are not, so how can this be? In endothelial cells, DHEA is demonstrated to increase the expression of nitric oxide synthase (NOS) and the subsequent secretion of nitric oxide (NO), which is commonly known to regulate the vascular system in a positive way for athletes. NO products are quite abundant these days, and everyone seems to love the pump that NO boosters provide, but DHEA has it all. It offers the positive cardiovascular pump and skeletal benefits of estrogens, plus the muscle-enhancing properties of androgens, without the elevated blood levels or side effects of either.
DHEA is also generally observed to decrease Sex Hormone-Binding Globulin (SHBG) and increase IGF-1 levels in the blood. These are both highly desirable effects because they discourage feedback suppression and promote additional growth. Another encouraging observation is that hCG treatment increases intratesticular DHEA concentrations. This makes a strong argument for the steroidogenic action of DHEA, rather than any suppressive potential, but this is not yet fully characterized. In addition to these peripheral steroidogenic effects, DHEA may also promote central steroidogenic processes by interaction with the NMDA receptor. This is only speculation because LH studies with consistent results in healthy men are hard to find.
So what's the practical potential of DHEA? In the gym (real world) DHEA can be expected to promote muscular density and hardness after just a few days of use. This rapid response seems related to its notable insulinomimetic activity, which is crucial to the anabolic effect of androgens. It also works well in practically any stack, and doesn't induce any discernable estrogenic or corticogenic sides.
Reducing cortisol and estrogen, and helping in weight loss, immune system strength, and anti-aging
Androsta-3,5-diene-7,17-dione (Androsta) is an aromatase inhibitor which binds very strongly with the aromatase enzyme. It's just as strong as aromasin, which is a very expensive drug sold by prescription only.
Androsta will also help reduce cortisol thanks to the ketone in the seventh position; hence, the reason it is also called 7-Keto. Cortisol is a nasty hormone that the body releases when it is stressed. This stress can be from work related stress, or even the stress we put our bodies through when we workout.
Being able to keep cortisol down will result in a great ability to lose weight, build muscle, and feel better overall. As athletes, we are dependent on our bodies ability to rebound from workouts. However, many people workout daily and are unable to build muscle, and a big reason why is cortisol. This is where Androsta comes in because it will help control cortisol during recovery.
During post cycle therapy, the ability to keep cortisol and estrogen in check is a double weapon to help preserve muscle and keep water and fat away. Many bodybuilders complain during PCT that they cannot retain their gains, so it is crucial that androsta is used during this time.
Studies have shown androsta can aid weight loss, strengthen immune system, and has anti-aging properties; likely a result of a domino effect from the cortisol suppressing properties. In rat studies, there was thermogenic activity discovered, which explains the weight loss benefits.
Androsta is the most powerful legal (not for long) natural aromatase inhibitor in existence. It is as powerful as aromasin, which is a drug. In addition, Androsta is excellent at controlling cortisol, helping you drop bodyfat and keep water retention away. Use during cycle, post cycle, or as a stand-alone to help you build more muscle and cut more fat.
3x stronger that Androsterone and roughly 80% the androgenic strength of Methyltestosterone
3-Andro is growing in popularity and being that it is DSHEA compliant, virtually side effect free and enhances other hormonal products when stacked in combination makes it very appealing to consumers. Customers want the latest and greatest in muscle building ingredients and 3-Andro is not only gaining customers attention, but the rumors of its effectiveness are spreading quickly. What makes this product so great is that it not only works well on its own, but it’s “stacking” potential is virtually endless.
3-Andro is the latest in muscle building prohormones to hit the market. One of the most defining ways to demonstrate the effectiveness of anabolic compounds is by comparing them to Testosterone and their androgenic potency vs various other androgens.
Percentages are calculated from Micrograms Equivalent to a International Unit, with Testosterone being comparative standard (15IU = 100%). Gisvold et al (Textbook of Organic Medicinal and Pharmaceutical Chemistry, 7th Ed., Chap. 20, p.761)
- 100.0% Testosterone
- 75.0% DHT 54.5%
- 17a-Methyltestosterone 43.9%
- 3-Andro / Dehydroandrosterol (Δ5-Androstene-3a,17b-diol) 15.0%
- Androsterone 12.5%
- Andro (Δ4-Androstenedione) 12.0%
- Androstanedione 3.8%
- Epitestosterone 3.0%
- 5-AD (Δ5-Androstene-3b,17b-diol) 2.1%
- Epiandrosterone 2.0% DHEA (Dehydroepiandrosterone)
By comparison, it is apparent that 3-Andro shows impressive androgenic potency, being about 3x stronger that Androsterone and possessing roughly 80% the androgenic strength of Methyltestosterone!
While it may be obscure, 3-Andro is no less a recognized endogenous hormone in animals, and its exogenous administration is expressly prohibited by some sports organizations such as WADA.
3-Andro does not affect blood lipids negatively (following dosing protocol) so cycle length can safely range from 6-12 weeks. 3-Andro does not require on cycle support supplements, however if stacked with other hormones it is recommended that a cycle support product be taken.
Enteric Capsule Technology: Increased Absorption
This delivery system is known as an enteric coating. This is usually only used with advanced pharmaceutical products.
The enteric coating that we use contains a pH sensitive polymer, which means that it remains intact in the acidic environment of the stomach (pH 1.5 - 3.5), protecting the contents of the tablet.
After passing through the stomach the coating then disintegrates in the small intestine (duodenum) which has an alkaline environment (pH 6.5 - 7.6).
The enteric coating is inert and simply passes through your system without any effect at all. The coating we use is manufactured by Colorcon, a world leader in the development and manufacturing of delayed and immediate release coatings for both pharmaceutical and dietary supplement products. This coating has been thoroughly proven for both safety and efficacy.
Apart from the protection that this system provides for those ingredients in our enteric coated products which could be damaged by stomach acid, it also prevents any irritation of the gastric mucosa in the stomach, which is common with many supplements and drugs.
What are the Benefits of Enteric Coated Capsules?
For some formulations, Enteric Coated Capsules are an ideal choice. This is because they:
Overwhelmingly increase absorption rates - The absorption of high quality supplements can increase from as low as 10% (depending on the individual) to 80% or more.
Will not dissolve in the mouth – Enteric Coated Capsules are perfect for drugs that are acid-activated, as they prevent the drug from activating in the mouth or esophagus.
Will not irritate the stomach – Many drugs, such as aspirin, can irritate the stomach. Because they pass through the stomach intact, Enteric Coated Capsules avoid this problem.
Can preserve enzyme activity – Most tablets break down in the highly acidic environment of the stomach. Unfortunately, depending on the product’s formulation, this acidic environment can also negatively impact the desired enzyme activity. Enteric Coated Capsules protect the enzymes so that they can be absorbed, at their highest activity levels, in the small intestine.
Take longer to dissolve – While most capsules dissolve within 15 minutes, Enteric Coated Capsules do not dissolve until approximately one to two hours after ingestion, when they reach the small intestine. These capsules can therefore provide a “timed-release” affect.
Although enteric coating is a common technology employed with expensive pharmaceutical medications, it is rarely seen in the nutritional supplement industry!
That’s because most supplements are manufactured to a price rather than from a ‘best science’ perspective. Pharmaceuticals always work because they must be based on ‘best science’ since FDA regulations require proof that they work.
The manufacturer of Xtend-Life claims over 80% absorption of ingredients when using enteric coated capsules. An extremely high level for a nutritional or dietary supplement.
Some experts believe that (in non-enteric coated products) the bioavailability of vitamins (i.e. all the contents) is only 10-15% due to damage from gastric juices and enzymes in the stomach. This is a gray area however as there is little conclusive research available dealing with absorption rates since so many individual factors come into play from person to person.
As a dietary Supplement, take one (1) capsule twice per day, ideally timing one dose one hour prior to working out. Take daily for up to 12 consecutive weeks, followed by 4 weeks of Breakthrough BALANCE. DO NOT EXCEED 2 capsules in a 24-hour period. Users may resume use of GENETIX after at least one month of discontinued use. Breakthrough DEFENSE is recommended, but not necessary while taking GENETIX. Anti-estrogen is built in and not needed to add. Recommended for adult men Only. NOT recommended for women.
Consult with your physician before using this product. Do not take this supplement if you have any pre-existing medical conditions. This product should not be used by anyone under the age of 18. Athletes, check with your testing organization before using. User assumes all risks and liabilities related to use of this product. Keep out of the reach of children. Keep in a cool, dry place.